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FDA-led research team discovers an autoimmune mechanism for serious drug-induced adverse reactions
date:May 23, 2012
e allergic shock and even death.


Abacavir interacts with molecules in the immune system called Human Leukocyte Antigens (HLAs), specifically HLA-B*5701, which help the body to distinguish self versus foreign proteins. The drug can cause HLA-B*5701 to present for the first time certain self proteins that the body has not seen before. Because the body has not previously recognized these self proteins, it mistakenly treats them as foreign, resulting in the body trying to destroy its own tissues.

07/12 12:08